2 edition of Transcriptional regulation of the human insulin gene found in the catalog.
Transcriptional regulation of the human insulin gene
Andrew Richard Clark
Thesis (Ph.D) - University of Birmingham, Department of Medicine.
|Statement||by Andrew Richard Clark.|
Positive and negative transcriptional regulation differ in that: there must be mechanisms of gene regulation that promote insulin expression in the specialized pancreatic cells and prevent insulin expression in all other cells. The human body contains approximately major cell types. They look and function differently from one. SNHG7, a member of the small nucleolar host gene family, is a highly-expressed lncRNA that is consistently and significantly down-regulated by IGF1 signaling by a post-transcriptional . Gene Expression Regulation () Transcription Factors () Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression. Shen, Li-Wen.
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2. The Human Insulin Receptor Gene. The human insulin receptor gene spans ~ kb and is composed of 22 exons; the first 11 exons encode the extracellular alpha subunit and the remaining 11 exons encode the intracellular beta subunit. Cloning of INSR cDNA was first reported in by two groups [11,12].
The predicted transcript lengths differed by 36 bp, which reflects alternative splicing of exons Author: Sandhya Payankaulam, Ana-Maria Raicu, David N. Arnosti. Whelan J, Cordle SR, Henderson E, Weil PA, Stein R () Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene : Isabella Artner, Roland Stein.
hormones. Insulin gene transcription is a unique feature of the, cell and has been found to increase in response to glucose (1, 2) by mechanisms that are not clearly understood. Early gene transfection analysis demonstrated the pres-ence of transcriptional control elements within the 5' flanking region of the rat insulin I gene (3).
Although. Moreover, our data consistently support the hypothesis that a putative defect in this nuclear binding protein may cause insulin receptor dysfunction with subsequent impairment of insulin signaling and action.—Brunetti, A., Manfioletti, G., Chiefari, E., Goldfine, I.
D., Foti, D. Transcriptional regulation of human insulin receptor gene by the Cited by: McKeon C. () Transcriptional Regulation of the Insulin Receptor Gene Promoter. In: Le Roith D., Raizada M.K. (eds) Current Directions in Insulin-Like Growth Factor Research.
Advances in Experimental Medicine and Biology, vol Cited by: 6. The insulin receptor gene encodes an evolutionarily conserved signaling protein with a wide spectrum of functions in metazoan development.
The insulin signaling pathway plays key roles in processes such as metabolic regulation, growth control, and neuronal : Sandhya Payankaulam, Ana-Maria Raicu, David N. Arnosti.
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Petersen HV(1), Serup P, Leonard J, Michelsen BK, Madsen OD.
Author information: (1)Hagedorn Research Institute, Gentofte, by: In summary, insulin regulation of SREBP-1c synthesis and/or cleavage and/or transactivating potential, is likely to underlie the regulation of the fatty acid biosynthetic genes, while subtle, if poorly understood, differences in regulation and function of the SREBP isoforms allow different, if overlapping, patterns of gene regulation by insulin and by: 2.
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. H V Petersen, P Serup, J Leonard, B K Michelsen Cited by: Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes H V Petersen, P Serup, J Leonard, B K Michelsen.
Recent studies of the insulin gene promoter and the transcription factors that regulate it have expanded our understanding of both how the production of insulin is restricted to the pancreatic β-cell, and how that production is regulated by physiologic signals such as glucose.A picture is emerging in which an elaborate set of transcription factors binds to specific sequences along the Cited by: The human insulin-like growth factor II (IGF-II) gene consists of nine exons and has four promoters (P1–4).
The promoters exhibit a tissue-specific and developmental stage-dependent expression Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Cited by: Transcriptional Regulation of Insulin Gene Expression 23 and inducible knockout strategies to more precisely evaluate the importance of potential regulators in islet cell formation and function.
KLF15 Is a Transcriptional Regulator of the Human 17β-Hydroxysteroid Dehydrogenase Type 5 Gene. A Potential Link between Regulation of Testosterone Production and Fat Stores in Women Xiaofei Du, Robert L. Rosenfield, and Kenan QinCited by: Prokaryotic transcriptional regulation Iftryptophanis present the repressor‐tryptophancomplexbindsto operator => nomRNAexpression ofstructural genes.
If tryptophan and its gene expression is repressed they still found that transcription was initiated, there was “RNA” fragments of leader seq. Transcriptional regulation by insulin: from the receptor to the gene Catherine Mounier, a Barry I. Posner b a BioMed, Department of Biological Science, University of Quebec in Montreal, President Kennedy, Montreal, QC H2X 3Y7, by: THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol.No.
24, Issue of Aug pp.Printed in U. S.A. Transcriptional Regulation of the Human Insulin. In this study, the effects of insulin and glucagon administration on the glycolipid metabolism of blunt snout bream (Megalobrama amblycephala) were (average weight ± g) were intraperitoneally injected with a % saline solution, a bovine insulin ( mg/kg body weight) and a bovine glucagon ( mg/kg body weight), : Hua-Juan Shi, Wen-Bin Liu, Chao Xu, Li Zhang, Jie Liu, Ding-Dong Zhang, Ling Zhang, Xiang-Fei Li.
Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI(Y). In earlier studies, we reported reduced human insulin receptor (hIR) mRNA levels, insulin binding and insulin responsiveness in U human promonocytic cells treated with aldosterone.
The mechanism for this inhibition could be diminished IR gene transcription, since Cited by: Defective regulation of gene expression may be involved in the pathogenesis of type 2 diabetes.
We have characterized the concerted regulation by insulin (3-h hyperinsulinemic clamp) of the expression of 10 genes related to insulin action in skeletal muscle and in subcutaneous adipose tissue, and we have verified whether a defective regulation of some of them could be specifically Cited by: Transcriptional regulation of human insulin receptor gene by the high-mobility group protein HMGI (Y).
Transcriptional Regulation of the Human Gonadotropin Releasing Hormone Receptor Gene on *FREE* shipping on qualifying offers. The molecular basis of the transcriptional control of the UCP1 gene has been extensively studied using mouse and rat UCP1 genes, as well as the human gene.
Transcriptional control relies on regulatory regions in the 5′ non-coding region of the gene; notably, the cis-acting structure of this regulation is largely shared by rodent and human by: FEBS FEBS Letters () Cloning and sequencing of the 5' region of the human glucosephosphatase gene" transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cells** Dieter Schmoll***, Bernard B.
Allan***, Ann Burchell* Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, University of Dundee, Dundee, DDI 9SY, UK Cited by: Transcriptional regulation of the human insulin receptor promoter Article (PDF Available) in Journal of Biological Chemistry (24) September with 27 Reads How we measure 'reads'.
Transcriptional Regulation of Gene Expression in Eukaryotes: The variation in the rate of transcription often regulates gene expression. Interactions between RNA polymerase II and basal transcription factors leading to the formation of the transcription initiation complex influence the rate of transcription.
Treatment with 10(-8) M 1,dihydroxyvitamin D(3) for 24 h causes transcriptional activation of the human insulin receptor gene in U human promonocytic cells. This article is from PLoS ONE, volume ctThe High-Mobility Group AT-Hook 1 (HMGA1) protein is an architectural transcription factor that binds to.
The p53 protein regulates the transcription of many target genes in response to a wide variety of stress signals. This Analysis article presents the most comprehensive list so far of human Cited by: Although insulin and glucagon were long known as critical in regulating gene expression, it is only recently that carbohydrates also have been shown to play a key role in transcriptional regulation.
DNA sequences and DNA binding complexes involved in the glucose-regulated gene expression have been characterized recently in liver and β by: RNA is transcribed, but must be processed into a mature form before translation can begin.
This processing that takes place after an RNA molecule has been transcribed, but before it is translated into a protein, is called post-transcriptional with the epigenetic and transcriptional stages of processing, this post-transcriptional step can also be regulated to control gene.
The insulin-responsive glucose transporter 4 (GLUT4) plays a key role in glucose uptake and metabolism in insulin target tissues. Being a rate-limiting step in glucose metabolism, the expression and function of the GLUT4 isoform has been extensively studied and found to be tightly regulated at both mRNA and protein by: The gene extends over approximately 12 kb of mouse chromosome 7 and is located 18 kb 3′ to the insulin 2 gene and in the same transcriptional polarity.
Exons 1–3 encode distinct 5′ untranslated regions and are transcribed by three different promoters, P 1, P 2, and P 3, into three IGF-II mRNAs sharing common coding and 3 Cited by: Further 5′ from the transcriptional start site, an insulin response core element (IRCE) is located between nucleotides − and − This element binds to the ubiquitous transcription factor Sp1 and is responsible for the induction of the apo A-I gene by by: Buy Transcriptional regulation of the insulin gene by Steven Goodison (ISBN:) from Amazon's Book Store.
Everyday low prices and free delivery on eligible : Steven Goodison. Glucose is the primary regulator of insulin granule release from pancreatic islets. In rodent islets, the role of glucose in the acute regulation of insulin gene transcription has remained unclear, primarily because the abundance and long half-life of insulin mRNA confounds analysis of transcription by traditional methods that measure steady-state mRNA by: Treatment with 10(-8) M 1,dihydroxyvitamin D(3) for 24 h causes transcriptional activation of the human insulin receptor gene in U human promonocytic cells.
The activation seems to potentiate the response to insulin in terms of glucose oxidation. Insulin is the most important hormone regulating energy metabolism. Since its discovery, insulin has been subjected to extensive research to elucidate its activity in a variety of metabolic processes, including glucose homeostasis, substrate metabolism, gene transcription, protein synthesis, and protein degradation ().A considerable body of evidence supports the hypothesis that Cited by: Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in the mobilization of fatty acids from adipose tissue, thus determining the supply of energy substrates in the body.
HSL mRNA was positively regulated by glucose in human adipocytes. Pools of stably transfected 3T3-FA adipocytes were generated with human adipocyte HSL promoter fragments from −2,/+38 to −31/+38 bp linked Cited by:. Gene regulation makes cells different. Gene regulation is how a cell controls which genes, out of the many genes in its genome, are “turned on” (expressed).
Thanks to gene regulation, each cell type in your body has a different set of active genes—despite the fact that almost all the cells of your body contain the exact same DNA.Insulin controls gene transcription by modifying the binding of transcription factors on insulin-response elements or by regulating their transcriptional activities.
Different insulin-signaling cascades have been characterized as mediating the insulin effect on gene transcription. In this review, we analyze recent data on the molecular Cited by: 13 2. Transcriptional Regulation of Insulin Gene Expression Isabella Artner andRoland Stein Summary.
The insulin gene is expressed exclusively in the beta cells of the.